Publications

2026

Life-cycle trajectory inference links temperature-gated progenitors to reproductive fate

Vaidya G, Lagodny E, Girish A, Mellado Fuentes AM, Ross E, Robb S, Mirkes K, Yavru D, Khan AUM, Tischer C, Dorrity MW†, Vu HTK†

bioRxiv. 2026.

Preprint

Quantitative mapping of heterochrony to species-specific phenotypes

Bourn JJ, Knoblich SA, Kneeshaw SJ, Benjaminsen J, Zilova L, Aulehla A, Saunders L, Wittbrodt J, Birney E, Dorrity MW

bioRxiv. 2026.

Preprint

Tissue rigidity phase transition shapes morphogen gradients

Autorino C, Khoromskaia D, Harari L, Floris E, Booth H, Pallares-Cartes C, Petrasiunaite V, Dorrity MW, Corominas-Murtra B, Hadjivasiliou Z, Petridou NI

Nature Cell Biology. 2026.

Paper

2025

High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes

Yildiz U, Claringbould A, Marttinen M, Campos-Fornes V, Lamprousi M, Saraswat M, Saver M, Bunina D, Dorrity MW, Zaugg J, Noh KM

bioRxiv. 2025.

Preprint

2024

Degrees of freedom: temperature's influence on developmental rate

Bourn JJ, Dorrity MW

Current Opinion in Genetics & Development. 2024; 85:102155.

Paper

2023

Proteostasis governs differential temperature sensitivity across embryonic cell types

Dorrity MW†, Saunders LM, Duran M, Srivatsan SR, Barkan E, Jackson DL, ... Trapnell C†

Cell. 2023; 186(23):5015-5027.

Paper

Embryo-scale reverse genetics at single-cell resolution

Saunders LM, Srivatsan SR, Duran M, Dorrity MW, Ewing B, Linbo TH, ... Trapnell C

Nature. 2023.

Paper

2022

Dynamic chromatin accessibility deploys heterotypic cis/trans-acting factors driving stomatal cell-fate commitment

Kim ED, Dorrity MW, Fitzgerald BA, Seo H, Sepuru KM, Queitsch C, Mitsuda N, Han SK, Torii KU

Nature Plants. 2022.

Paper

2021

The regulatory landscape of Arabidopsis thaliana roots at single-cell resolution

Dorrity MW, Alexandre C, Hamm M, Vigil A, Fields S, Queitsch C, Cuperus J

Nature Communications. 2021; 12(1):3334.

Paper

2020

Dimensionality reduction by UMAP to visualize physical and genetic interactions

Dorrity MW, Saunders LM, Queitsch C, Fields S, Trapnell C

Nature Communications. 2020; 11:1537.

Paper

Identification of plant enhancers and their constituent elements by STARR-seq in tobacco leaves

Jores T, Tonnies J, Dorrity MW, Cuperus JT, Fields S, Queitsch C

The Plant Cell. 2020; 32:2120-2131.

Paper

Binding and regulation of transcription by yeast Ste12 variants to drive mating and invasion phenotypes

Zhou W, Dorrity MW, Bubb KL, Queitsch C, Fields S

Genetics. 2020; 214(2):397-407.

Paper

Transcriptional re-wiring by mutation of the yeast Hsf1 oligomerization domain

Morton EA, Dorrity MW, Zhou W, Fields S, Queitsch C

bioRxiv. 2020.

Preprint

2019

High-throughput identification of dominant negative polypeptides in yeast

Dorrity MW, Queitsch C, Fields S

Nature Methods. 2019; 16:413.

Paper

Dynamics of gene expression in single root cells of Arabidopsis thaliana

Jean-Baptiste K, McFaline-Figueroa JL, Alexandre CM, Dorrity MW, Saunders L, Bubb KL, Trapnell C, Fields S, Queitsch C, Cuperus JT

The Plant Cell. 2019; 31:993-1011.

Paper

2018

Preferences in a trait decision determined by transcription factor variants

Dorrity MW, Cuperus JT, Carlisle JA, Fields S, Queitsch C

Proceedings of the National Academy of Sciences. 2018; 115:E7997-E8006.

Paper

Profiling of accessible chromatin regions across multiple plant species and cell types reveals common gene regulatory principles and new control modules

Maher KA, Bajic M, Kajala K, Reynoso M, Pauluzzi G, West DA, Zumstein K, Woodhouse M, Bubb K, Dorrity MW, Queitsch C

The Plant Cell. 2018; 30:15-36.

Paper

2017

Complex relationships between chromatin accessibility, sequence divergence, and gene expression in Arabidopsis thaliana

Alexandre CM, Urton JR, Jean-Baptiste K, Huddleston J, Dorrity MW, Cuperus JT, Sullivan AM, Bemm F, Jolic D, Arsovski AA, Thompson A, Queitsch C

Molecular Biology and Evolution. 2017; 35:837-854.

Paper

2013

Identification of novel loci regulating interspecific variation in root morphology and cellular development in tomato

Ron M, Dorrity MW, de Lucas M, Toal T, Hernandez RI, Little SA, Maloof JN, Kliebenstein DJ, Brady SM

Plant Physiology. 2013; 162:755-768.

Paper